Tauopathies as clinicopathological entities
نویسندگان
چکیده
منابع مشابه
Clinicopathological features of the tauopathies.
Developments in molecular neuropathology have led to protein-based classification systems for neurodegenerative disorders. Key proteins include alpha-synuclein, amyloid and tau. Alternative mRNA splicing and post-translational change, induced by a bewildering variety of protein modifying processes such as phosphorylation and ubiquitination, have generated insights into new mechanisms of selecti...
متن کاملAnimal Models of Tauopathies
The discovery of mutations in the tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) (1–4) has demonstrated that tau dysfunction can result in neurodegeneration and has allowed researchers to generate transgenic models of the human tauopathies (5) (see Table 1 for summary). Transgenic models permit studies on the mechanisms of formation of filamentous tau les...
متن کاملInitiatives as Knowledge-Creating Entities
Initiatives are ‘a principle mechanism through which organizations develop new competitive advantages. This paper proposes a view of initiatives as processes that recombine previously disconnected knowledge domains, with the firm’s knowledge base serving as a platform from which the initiative creates its own knowledge base. During this process initiative members couple themselves tighter in or...
متن کاملTau protein as a differential biomarker of tauopathies.
Microtubule-associated Tau proteins are the basic component of intraneuronal and glial inclusions observed in many neurological disorders, the so-called tauopathies. Many etiological factors, phosphorylation, splicing, and mutations, relate Tau proteins to neurodegeneration. Molecular analysis has revealed that hyperphosphorylation and abnormal phosphorylation might be one of the important even...
متن کاملTransgenic animal models of tauopathies.
Tauopathies are a group of neurodegenerative disorders that include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases with prominent tau pathology. Research advances in the last several decades have characterized and defined tau neuropathologies of both neuron and glia in these diverse disorders and this has stimulated de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Parkinsonism & Related Disorders
سال: 2016
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2015.09.020